publication . Article . 2012

Common Genetic Variants and Gene-Expression Changes Associated with Bipolar Disorder Are Over-Represented in Brain Signaling Pathway Genes

Inti Pedroso; Anbarasu Lourdusamy; Marcella Rietschel; Markus M. Nöthen; Sven Cichon; Peter McGuffin; Ammar Al-Chalabi; Michael R. Barnes; Gerome Breen;
Open Access English
  • Published: 01 Jan 2012 Journal: Biological Psychiatry, volume 72, issue 4, pages 311-317 (issn: 0006-3223, Copyright policy)
  • Publisher: ELSEVIER SCIENCE INC
  • Country: Germany
Abstract
Background Despite high heritability, the genetic variants influencing bipolar disorder (BD) susceptibility remain largely unknown. Low statistical power to detect the small effect-size alleles believed to underlie much of the genetic risk and possible heterogeneity between cohorts are an increasing concern. Integrative biology approaches might offer advantages over genetic analysis alone by combining different genomic datasets at the higher level of biological processes rather than the level of specific genetic variants or genes. We employed this strategy to identify biological processes involved in BD etiopathology. Method Three genome-wide association studies...
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free text keywords: Biological Psychiatry, J, Bipolar disorder, depression, GWAS, mania, networks, pathways, postsynaptic density, systems biology, ipolar disorder, depression, GWAS, mania, networks, pathways, postsynaptic density, systems biology, Human Protein Reference Database, Genetics, Genome-wide association study, Gene, Biological network, Genetic association, Biology, Allele, Systems biology, Gene regulatory network, ddc:570
Funded by
UKRI| A Genome Wide Association study of Unipolar Depression
Project
  • Funder: UK Research and Innovation (UKRI)
  • Project Code: G0701420
  • Funding stream: MRC
,
WT
Project
  • Funder: Wellcome Trust (WT)
,
EC| EURO-MOTOR
Project
EURO-MOTOR
European multidisciplinary ALS network identification to cure motor neuron degeneration
  • Funder: European Commission (EC)
  • Project Code: 259867
  • Funding stream: FP7 | SP1 | HEALTH
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