HIV Integrase Inhibitors

Métifiot, Mathieu; Marchand, Christophe; Pommier, Yves;

Open Access

doi: 10.1016/b978-0-12-405880-4.00003-2

Published: 01 Jan 2013

Publisher: Zenodo

- Summary

Abstract

The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

Subjects by Vocabulary

Microsoft Academic Graph classification: Raltegravir medicine.drug medicine Integrase biology.protein biology Integrase inhibitor Viral integration Acquired immunodeficiency syndrome (AIDS) medicine.disease Dolutegravir chemistry.chemical_compound chemistry Virology Elvitegravir HIV Integrase Inhibitors

Medical Subject Headings: humanities virus diseases

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