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ZENODO; European Journal of Pharmacology
Article . 1988 . Peer-reviewed
License: Elsevier TDM
Data sources: ZENODO; Crossref
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European Journal of Pharmacology
Article
License: CC 0
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pharmacologic profile of mdma 3 4 methylenedioxymethamphetamine at various brain recognition sites

Authors: Battaglia, George; Brooks, Brian P.; Kulsakdinun, Chaiyaporn; De Souza, Errol B.;

pharmacologic profile of mdma 3 4 methylenedioxymethamphetamine at various brain recognition sites

Abstract

We report here an in vitro pharmacologic profile for MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites. The rank order of affinities of MDMA at various brain receptors and uptake sites are as follows: 5-HT uptake greater than alpha 2-adrenoceptors = 5-HT2 serotonin = M-1 muscarinic = H-1 histamine greater than norepinephrine uptake = M-2 muscarinic = alpha 1-adrenoceptors = beta-adrenoceptors greater than or equal to dopamine uptake = 5-HT1 serotonin much greater than D-2 dopamine greater than D-1 dopamine. MDMA exhibited negligible affinities (greater than 500 microM) at opioid (mu, delta and kappa), central-type benzodiazepine, and corticotropin-releasing factor receptors, and at choline uptake sites and calcium channels.

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Keywords

Male, Brain Chemistry, Receptors, Drug, N-Methyl-3,4-methylenedioxyamphetamine, Amphetamines, Rats, Animals, 3,4-Methylenedioxyamphetamine

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    262
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Top 1%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
262
Top 10%
Top 1%
Top 10%
Green
hybrid