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The pathogenesis of keratitis

descriptionPublicationkeyboard_double_arrow_right Article 01 May 1999 English Publisher:Elsevier BVJournal:Microbes and Infection, volume 1, pages 437-443 (issn: 1286-4579,

Authors: James P. McCulley; Henry Leher; Hassan Alizadeh; Jerry Y. Niederkorn;

doi: 10.1016/s1286-4579(99)80047-1

pmid: 10602676

The pathogenesis of keratitis

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Abstract

Free-living amoebae of the genus Acanthamoeba produce a progressive, blinding infection of the corneal surface. The pathogenesis of Acanthamoeba keratitis involves parasite-mediated cytolysis and phagocytosis of corneal epithelial cells and induction of programmed cell death. Acanthamoeba spp. elaborate a variety of proteases which may facilitate cytolysis of the corneal epithelium, invasion of the extracellular matrix, and dissolution of the corneal stromal matrix.

Related Organizations

The University of Texas Southwestern Medical Center
United States

Keywords

Cornea, Mice, Acanthamoeba Keratitis, Animals, Humans, Acanthamoeba

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	160
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average