
The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.
Models, Molecular, Sinu virus, 570, Insect-specific viruses, Ortomixovirus, Molecular Sequence Data, 610, Genome, Viral, Colombia, Orthomyxoviridae, Evolution, Molecular, Viral Proteins, Culicidae, Thogotovirus genus, Animals, Amino Acid Sequence, Thogotovirus, Phylogeny, Orthomyxoviruses
Models, Molecular, Sinu virus, 570, Insect-specific viruses, Ortomixovirus, Molecular Sequence Data, 610, Genome, Viral, Colombia, Orthomyxoviridae, Evolution, Molecular, Viral Proteins, Culicidae, Thogotovirus genus, Animals, Amino Acid Sequence, Thogotovirus, Phylogeny, Orthomyxoviruses
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