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On the Acoustic Properties of Vaporized Submicron Perfluorocarbon Droplets
Copyright policy )On the Acoustic Properties of Vaporized Submicron Perfluorocarbon Droplets
The acoustic characteristics of microbubbles created from vaporized submicron perfluorocarbon droplets with fluorosurfactant coating are examined. Utilizing ultra-high-speed optical imaging, the acoustic response of individual microbubbles to low-intensity diagnostic ultrasound was observed on clinically relevant time scales of hundreds of milliseconds after vaporization. It was found that the vaporized droplets oscillate non-linearly and exhibit a resonant bubble size shift and increased damping relative to uncoated gas bubbles due to the presence of coating material. Unlike the commercially available lipid-coated ultrasound contrast agents, which may exhibit compression-only behavior, vaporized droplets may exhibit expansion-dominated oscillations. It was further observed that the non-linearity of the acoustic response of the bubbles was comparable to that of SonoVue microbubbles. These results suggest that vaporized submicron perfluorocarbon droplets possess the acoustic characteristics necessary for their potential use as ultrasound contrast agents in clinical practice. (C) 2014 World Federation for Ultrasound in Medicine & Biology.
- University of Toronto Canada
- Erasmus University Rotterdam Netherlands
- Erasmus University Rotterdam Netherlands
- University of Twente Netherlands
Microsoft Academic Graph classification: Materials science Diagnostic ultrasound Bubble engineering.material chemistry.chemical_compound Optics Coating Vaporization Fluorosurfactant business.industry Ultrasound Clinical Practice chemistry engineering Microbubbles Optoelectronics business
Medical Subject Headings: complex mixtures technology, industry, and agriculture
Acoustics and Ultrasonics, Biophysics, Contrast Media, Image Processing, Computer-Assisted, Radiology, Nuclear Medicine and imaging, Fluorocarbons, Microbubbles, Radiological and Ultrasound Technology, Acoustics, Equipment Design, 2023 OA procedure, Volatilization
Acoustics and Ultrasonics, Biophysics, Contrast Media, Image Processing, Computer-Assisted, Radiology, Nuclear Medicine and imaging, Fluorocarbons, Microbubbles, Radiological and Ultrasound Technology, Acoustics, Equipment Design, 2023 OA procedure, Volatilization
Microsoft Academic Graph classification: Materials science Diagnostic ultrasound Bubble engineering.material chemistry.chemical_compound Optics Coating Vaporization Fluorosurfactant business.industry Ultrasound Clinical Practice chemistry engineering Microbubbles Optoelectronics business
Medical Subject Headings: complex mixtures technology, industry, and agriculture
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).34 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10% citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).34 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
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- Canadian Institutes of Health Research (CIHR)
- University of Toronto Canada
- Erasmus University Rotterdam Netherlands
- Erasmus University Rotterdam Netherlands
- University of Twente Netherlands
The acoustic characteristics of microbubbles created from vaporized submicron perfluorocarbon droplets with fluorosurfactant coating are examined. Utilizing ultra-high-speed optical imaging, the acoustic response of individual microbubbles to low-intensity diagnostic ultrasound was observed on clinically relevant time scales of hundreds of milliseconds after vaporization. It was found that the vaporized droplets oscillate non-linearly and exhibit a resonant bubble size shift and increased damping relative to uncoated gas bubbles due to the presence of coating material. Unlike the commercially available lipid-coated ultrasound contrast agents, which may exhibit compression-only behavior, vaporized droplets may exhibit expansion-dominated oscillations. It was further observed that the non-linearity of the acoustic response of the bubbles was comparable to that of SonoVue microbubbles. These results suggest that vaporized submicron perfluorocarbon droplets possess the acoustic characteristics necessary for their potential use as ultrasound contrast agents in clinical practice. (C) 2014 World Federation for Ultrasound in Medicine & Biology.