KSHV microRNAs: Tricks of the Devil

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2017 English Publisher:Elsevier BVJournal:Trends in Microbiology, volume 25, pages 648-661 (issn: 0966-842X,

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Authors: Jie, Qin; Wan, Li; Shou-Jiang, Gao; Chun, Lu;

doi: 10.1016/j.tim.2017.02.002

pmid: 28259385

pmc: PMC6904892

KSHV microRNAs: Tricks of the Devil

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Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS), a vascular tumor frequently found in immunodeficient individuals. KSHV encodes 12 pre-microRNAs (pre-miRNAs), which are processed into 25 mature microRNAs (miRNAs). KSHV miRNAs maintain KSHV latency, enhance angiogenesis and dissemination of the infected cells, and interfere with the host immune system by regulating viral and cellular gene expression, ultimately contributing to KS development. In this review, we briefly introduce the biogenesis of miRNAs and then describe the recent advances in defining the roles and mechanisms of action of KSHV miRNAs in KS development.

Related Organizations

University of Southern California
United States
University of California System
United States
Nanjing Medical University
China (People's Republic of)
State Key Laboratory of Reproductive Medicine
China (People's Republic of)

Keywords

Neovascularization, Pathologic, Cell Line, Virus Latency, MicroRNAs, Herpesvirus 8, Human, Host-Pathogen Interactions, Humans, RNA, Viral, Virus Activation, Sarcoma, Kaposi

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