cGAS Conducts Micronuclei DNA Surveillance

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2017 English Publisher:Elsevier BVJournal:Trends in Cell Biology, volume 27, pages 697-698 (issn: 0962-8924,

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Authors: Carina C, de Oliveira Mann; Philip J, Kranzusch;

doi: 10.1016/j.tcb.2017.08.007

pmid: 28882413

cGAS Conducts Micronuclei DNA Surveillance

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Abstract

DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the immune sensor cyclic GMP-AMP synthase (cGAS) in micronuclei leads to a cell-cycle-dependent proinflammatory response following DNA damage.

Related Organizations

Harvard University
United States
Dana-Farber Cancer Institute
United States

Keywords

Cell Nucleus, Inflammation, Cytoplasm, Cell Cycle, DNA, Immunity, Innate, Animals, Humans, Nucleotides, Cyclic, DNA Damage, Signal Transduction

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