Undescribed specialised metabolites from the endophytic fungus Emericella sp. XL029 and their antimicrobial activities

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2022 English Publisher:Elsevier BVJournal:Phytochemistry, volume 202, page 113,303 (issn: 0031-9422,

Authors: Peng-Jie, Xian; Shu-Zhi, Liu; Wen-Jing, Wang; Sheng-Xiang, Yang; Zhang, Feng; Xiao-Long, Yang;

doi: 10.1016/j.phytochem.2022.113303

pmid: 35787351

Undescribed specialised metabolites from the endophytic fungus Emericella sp. XL029 and their antimicrobial activities

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Abstract

The fungus Emericella sp. XL029 isolated from leaves of Panax notoginseng was investigated for agents with potential antibacterial and antifungal activities using a one strain-many compounds (OSMAC) strategy. Fifteen compounds, including seven undescribed structures, were obtained from this species. Their structures were confirmed by extensive spectroscopic data, single-crystal X-ray crystallography and quantum chemistry calculations. Emerlactam A exhibited better antibacterial activity against multidrug-resistant Enterococcus faecium and antifungal activity against Helminthosporium maydis, with an MIC value of 12.5 μg/mL. Quiannulatic acid displayed significant antibacterial activity against multidrug-resistant Enterococcus faecium and multidrug-resistant Enterococcus faecalis with MIC values of 1.56 μg/mL and 3.13 μg/mL, respectively. 5-alkenylresorcinol exhibited significant antifungal activity against all tested phytopathogenic fungi with MIC values ranging from 6.25 to 12.5 μg/mL.

Related Organizations

Zhejiang Ocean University
China (People's Republic of)
Chongqing University
China (People's Republic of)
South Central University for Nationalities
China (People's Republic of)

Keywords

Antifungal Agents, Emericella, Molecular Structure, Fungi, Microbial Sensitivity Tests, Anti-Bacterial Agents

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