A 60-year-old woman with leukoderma, retired, presented with a main complaint of “ball in the roof of the mouth,” evolution of 10 years, without change of size, and she had used a partial removable prosthesis for 20 years. However, in the last month she began to feel pain. She was a smoker for 10 years (1 pack/d). Clinical examination showed a nodule on the palate, normocorate, in the tooth region 24/25, 1 cm in diameter, hard to palpation, smooth surface, with defined and regular borders. An excisional biopsy was performed, which revealed gingival mucosa with hyperplastic parakeratinized squamous epithelium, and submucosa with fascicular arrangements of young fibroblast cells in dense bundles of collagen fibers. In the depth connective tissue, salivary glands with acinar atrophy and mononuclear inflammatory infiltrate and ductal dilation were noted. The diagnosis was fibroma, benign neoplasm uncommon in the oral mucosa. In the postoperative period, good healing was observed without recurrences.