publication . Article . 2004

Increased cerebrospinal fluid levels of transforming growth factor-β1 in Alzheimer’s disease

Henrik Zetterberg; Niels Andreasen; Kaj Blennow;
  • Published: 22 Jun 2004 Journal: Neuroscience Letters, volume 367, pages 194-196 (issn: 0304-3940, Copyright policy)
  • Publisher: Elsevier BV
Abstract Accumulation of β-amyloid (Aβ) in senile plaques in specific brain regions is a key event in the development of Alzheimer’s disease (AD). Expression of transforming growth factor-β1 (TGF-β1), a regulator of brain responses to inflammation and injury, has been correlated with Aβ accumulation, aggregation and clearance in transgenic mice and increased production of amyloid precursor protein (APP) followed by Aβ generation in murine and human astrocyte cultures. Here, we compared TGF-β1 levels in cerebrospinal fluid (CSF) from 20 AD patients and 20 healthy controls and correlated TGF-β1 to intrathecal levels of the amyloidogenic 42-amino acid fragment of A...
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free text keywords: Alzheimer's disease, medicine.disease, medicine, Cerebrospinal fluid, Tau protein, biology.protein, biology, Amyloid precursor protein, Senile plaques, Endocrinology, medicine.medical_specialty, TGF beta 1, business.industry, business, Transforming growth factor, Amyloid, Internal medicine
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