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Publication . Article . 2017

Microbiome of HIV-infected people

Grégory Dubourg; Mathieu Surenaud; Yves Levy; Sophie Hue; Didier Raoult;
Open Access
English
Published: 01 May 2017
Publisher: HAL CCSD
Country: France
Abstract
International audience; Consistent interactions between the gut microbiome and adaptive immunity recently led several research groups to evaluate modifications of human gut microbiota composition during HIV infection. Herein we propose to review the shifts reported in infected individuals, as their correlation to disease progression. Though the gut microbiota is consistently altered in HIV individuals, the literature reveals several discrepancies, such as changes in microbial diversity associated with HIV status, taxa modified in infected subjects or influence of ART on gut flora restoration. Similarly, mechanisms involved in interactions between gut bacteria and immunity are to date poorly elucidated, emphasizing the importance of understanding how microbes can promote HIV replication. Further research is needed to propose adjuvant therapeutics dedicated to controlling disease progression through gut microbiome restoration.
Subjects by Vocabulary

Medical Subject Headings: digestive system

Microsoft Academic Graph classification: Immunology Biology Microbiome Acquired immunodeficiency syndrome (AIDS) medicine.disease medicine Research groups Gut flora biology.organism_classification Acquired immune system Human gut Immunity Hiv infected

Subjects

HIV/AIDS, Gut, Microbiota, Translocation, Diversity, Immunity, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology, Infectious Diseases, Microbiology

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