Use of pegylated interferon in hypereosinophilic syndrome

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2012 English Publisher:Elsevier BVJournal:Leukemia Research, volume 36, pages 192-197 (issn: 0145-2126,

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Authors: Joseph H, Butterfield; Catherine R, Weiler;

doi: 10.1016/j.leukres.2011.09.026

pmid: 22118911

Use of pegylated interferon in hypereosinophilic syndrome

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Abstract

Scant information exists about pegylated interferons (PEG-IFNs) use for treating hypereosinophilic syndrome (HES). We describe 6 patients with HES-1 patient with a newly identified chromosomal abnormality-who received PEG-IFNs. PEG-IFN alpha-2b replaced interferon (IFN) alpha-2b for 4 patients and was initial treatment of 2 patients. PEG-IFN alpha-2a was substituted when PEG-IFN alpha-2b became unavailable. PEG-IFNs were well tolerated and controlled eosinophilia. The dose of PEG-IFNs often could be tapered and the interval between doses lengthened beyond 7 days. Adverse effects included dose-related increases in liver enzyme levels, hair loss, mild lymphopenia, and neutropenia. PEG-IFNs are effective treatment of HES.

Related Organizations

Mayo Clinic
United States

Keywords

Adult, Male, Interferon-alpha, Interferon alpha-2, Middle Aged, Antiviral Agents, Recombinant Proteins, Polyethylene Glycols, Treatment Outcome, Hypereosinophilic Syndrome, Humans, Female, Aged, Retrospective Studies

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