Effect of sulfonated steroids on steroidogenic cytochrome P450-dependent steroid hydroxylases
Copyright policy )Effect of sulfonated steroids on steroidogenic cytochrome P450-dependent steroid hydroxylases
In the last decades, sulfonated steroids evolved from inactive metabolites intended for excretion to highly relevant compounds involved in many physiological processes. Investigations of the impact of sulfonated steroids on the steroid hormone biosynthesis revealed that, on the one hand, these can serve as substrate for steroidogenic cytochromes P450 and, on the other hand, these are able to influence the catalytic properties of these enzymes. In this review the relevance of sulfonated steroids for the steroid hormone biosynthesis will be discussed.
- Saarland University Germany
Cytochrome P-450 Enzyme System, Dehydroepiandrosterone Sulfate, Pregnenolone, Steroid Hydroxylases, Animals, Humans, Steroids, Cholesterol Side-Chain Cleavage Enzyme, Hormones
Cytochrome P-450 Enzyme System, Dehydroepiandrosterone Sulfate, Pregnenolone, Steroid Hydroxylases, Animals, Humans, Steroids, Cholesterol Side-Chain Cleavage Enzyme, Hormones
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