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ZENODO; Journal of Functional Foods
2019 . Peer-reviewed
License: Elsevier TDM
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activation of epithelial cells by the major kiwifruit allergen act d 1 in human and mouse derived intestinal model

Authors: Nešić, Andrijana; Stam, Annemarie; Čavić, Milena; Ten Klooster, Jean Paul; Pieters, Raymond; Smit, Joost; Gavrović-Jankulović, Marija; +2 Authors

activation of epithelial cells by the major kiwifruit allergen act d 1 in human and mouse derived intestinal model

Abstract

© 2019 Elsevier Ltd In this study, two intestinal models were employed to assess the modulatory potential of a major kiwifruit allergen on the innate immunity of epithelial cells. Effects of Act d 1 were analyzed in terms of gene expression and structural changes of tight junction (TJ) proteins, as well as up-regulation of pro-inflammatory cytokines in Caco-2 cells and, for the first time, in mouse-derived intestinal 2-dimensional (2D) organoids. Biologically active Act d 1 induced up-regulation of TJ genes for CLDN-2, CLDN-3, CLDN-4, ZO-1, and on the protein level induced release of pro-inflammatory cytokines IL-1β, TNFα and IL-33 in both employed model systems. In 2D-organoids, active Act d 1 impaired the TJ protein networks of E-cadherin, claudin-3, and ZO-1. 2D-organoids generated from mouse intestine are a promising new model system for the assessment of allergen-induced intestinal cell responses and a useful tool for mitigation of risks associated with novel food proteins.

Countries
Serbia, Netherlands
Keywords

Nutrition. Foods and food supply, Food allergy, Pro-inflammatory cytokines, Act d 1, TX341-641, Cysteine protease, TJ proteins

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