Diacylglycerol kinase ζ deficiency in a non-CD4+ T-cell compartment leads to increased peanut hypersensitivity

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2011 English Publisher:Elsevier BVJournal:Journal of Allergy and Clinical Immunology, volume 128, pages 212-214 (issn: 0091-6749,

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Authors: Mike, Kulis; Chi-Keung, Wan; Balachandra K, Gorentla; A Wesley, Burks; Xiao-Ping, Zhong;

doi: 10.1016/j.jaci.2011.02.035

pmid: 21439625

pmc: PMC3129393

Diacylglycerol kinase ζ deficiency in a non-CD4+ T-cell compartment leads to increased peanut hypersensitivity

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Abstract

Peanut sensitization in diacylglycerol kinase zeta (DGKζ) deficient mice led to elevated peanut-IgE levels and severe anaphylaxis. DGKζ deficient CD4+T cells did not account for the phenotype. Future studies will determine which immune lineage caused increased food hypersensitivity.

Related Organizations

Duke University
United States
Duke University Hospital
United States
Duke Medical Center
United States

Keywords

Mice, Inbred C57BL, Diacylglycerol Kinase, Mice, T-Lymphocytes, Animals, Female, Peanut Hypersensitivity, Mice, Mutant Strains

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