publication . Article . 2011

Effects of n-3 Polyunsaturated Fatty Acids on Left Ventricular Function and Functional Capacity in Patients With Dilated Cardiomyopathy

Savina Nodari; Marco Triggiani; Umberto Campia; Alessandra Manerba; G Milesi; Bruno Mario Cesana; Mihai Gheorghiade; Livio Dei Cas;
Open Access English
  • Published: 01 Jan 2011 Journal: Journal of the American College of Cardiology, issue 7, pages 870-879 (issn: 07351097, Copyright policy)
  • Publisher: American College of Cardiology Foundation. Published by Elsevier Inc.
ObjectivesThis study was designed to test the effects of n-3 polyunsaturated fatty acids (PUFAs) on left ventricular (LV) systolic function in chronic heart failure (HF) due to nonischemic dilated cardiomyopathy (NICM).BackgroundOne hundred thirty-three patients with NICM and minimal symptoms on standard therapy were randomized to 2 g of n-3 PUFAs or placebo. LV function and functional capacity were assessed prospectively by echocardiography and cardiopulmonary exercise testing at baseline and at 12 months after randomization.MethodsPatients with chronic HF due to NICM and minimal symptoms while receiving evidence-based therapy were enrolled. LV function and fun...
free text keywords: cardiomyopathy, functional capacity, heart failure, nonischemic myocardial function, n-3 PUFAs, NYHA functional class, Therapeutics. Pharmacology, RM1-950, Diseases of the circulatory (Cardiovascular) system, RC666-701, Cardiology and Cardiovascular Medicine, Dilated cardiomyopathy, medicine.disease, medicine, In patient, Polyunsaturated fatty acid, chemistry.chemical_classification, chemistry, business.industry, business, Cardiology, medicine.medical_specialty, Ventricular function, Internal medicine, Heart failure, Cardiomyopathy, Randomization, Placebo
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