Tfh cells induce intratumoral tertiary lymphoid structures

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2022 English Publisher:Elsevier BVJournal:Trends in Immunology, volume 43, pages 274-276 (issn: 1471-4906,

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Authors: Lisa, Schmidleithner; Markus, Feuerer;

doi: 10.1016/j.it.2022.02.010

pmid: 35272934

Tfh cells induce intratumoral tertiary lymphoid structures

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Abstract

Tertiary lymphoid structures (TLS) are highly organized ectopic structures found in nonlymphoid organs under chronic inflammatory conditions, including cancer. A recent study by Chaurio et al. reports that repression of Satb1 in CD4+ T cells can lead to increased Tfh cell differentiation, driving intratumoral TLS formation, resulting in reduced tumor growth in mice.

Related Organizations

University of Regensburg
Germany
Leibniz Institute for Immunotherapy
Germany

Keywords

Mice, Tertiary Lymphoid Structures, T Follicular Helper Cells, Neoplasms, Animals, Humans, Cell Differentiation, Matrix Attachment Region Binding Proteins

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