FBXO38 Drives PD-1 to Destruction

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2019 English Publisher:Elsevier BVJournal:Trends in Immunology, volume 40, pages 81-83 (issn: 1471-4906,

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Authors: Taryn M, Serman; Michaela U, Gack;

doi: 10.1016/j.it.2018.12.005

pmid: 30609969

FBXO38 Drives PD-1 to Destruction

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Abstract

Aberrant expression of T cell-resident programmed cell death protein-1 (PD-1) is known to promote tumor progression. A recent study (Nature 2018;564:130-135) has now identified the E3 ubiquitin ligase FBXO38 as a crucial regulator of PD-1 protein turnover in T cells, providing a novel mechanism for potential use in cancer immunotherapy.

Related Organizations

University of Chicago
United States

Keywords

Neoplasms, T-Lymphocytes, Programmed Cell Death 1 Receptor, Ubiquitination, Humans, Immunotherapy

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