
pmid: 21616439
Familial Mediterranean fever is caused by mutations of the PYRIN protein. Chae et al. (2011) provide evidence for a ASC protein-dependent pathway of caspase-1 activation in which gain-of-function PYRIN mutations lead to IL-1β cytokine overproduction and inflammatory disease.
Infectious Diseases, Immunology, Immunology and Allergy
Infectious Diseases, Immunology, Immunology and Allergy
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