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Detection of hepatitis B surface antigen, hepatitis B core antigen, and hepatitis B virus DNA in parotid tissues

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2009 English Publisher:Elsevier BVJournal:International Journal of Infectious Diseases, volume 13, pages 20-23 (issn: 1201-9712,

Authors: Fuqiang Liu; Shi Wu Wen; Xue-Gong Fan; Tom Wong; J. Wu; Nengzhi Chen; Lizhang Chen; +1 Authors

doi: 10.1016/j.ijid.2008.03.015

pmid: 18539066

Detection of hepatitis B surface antigen, hepatitis B core antigen, and hepatitis B virus DNA in parotid tissues

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Abstract

To examine the presence of hepatitis B surface antigen (HBsAg), hepatitis B core antigen (HBcAg), and hepatitis B virus (HBV) DNA in parotid tissues from patients with positive serum HBV markers.HBsAg and HBcAg were examined in parotid biopsy tissues from patients with suspected parotid tumor and positive serum HBV markers by immunocytochemistry, and HBV DNA was detected in parotid tissues by PCR.Among the 22 patients with a parotid tumor, only one was pathologically confirmed as a neoplasm; all others were benign. HBsAg and HBcAg were present in parotid cells with positive rates of 45.5% (10/22) and 40.9% (9/22), respectively, with an overall positive rate of 54.5% (12/22). Of the 22 cases with serum markers of HBV infection, seven (31.8%) had both HBsAg and HBcAg in the parotid cells. HBV DNA was present in seven of the 12 samples in which hepatitis B antigen was detected (58.3%).HBV in saliva might originate from the infected salivary glands and the infectious saliva could transmit HBV.

Related Organizations

University of Ottawa
Canada
Central South University
China (People's Republic of)
Public Health Agency of Canada
Canada

Keywords

Microbiology (medical), Adult, Male, Hepatitis B virus, HBcAg, Adolescent, Polymerase Chain Reaction, Young Adult, HBsAg, Humans, Parotid Gland, Child, Aged, Hepatitis B Surface Antigens, Infant, Middle Aged, Hepatitis B, Hepatitis B Core Antigens, Immunohistochemistry, Infectious Diseases, HBV DNA, Child, Preschool, DNA, Viral, Female, Parotid tissue

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	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	22
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average