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RADaR
Article . 2016
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International Journal of Antimicrobial Agents
Article . 2016 . Peer-reviewed
License: Elsevier TDM
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lignin model compound in alginate hydrogel a strong antimicrobial agent with high potential in wound treatment

Authors: Dragica Spasojević; Danica Zmejkoski; Jasmina Glamočlija; Miloš Nikolić; Marina Soković; Verica Milošević; Ivana Jarić; +6 Authors

lignin model compound in alginate hydrogel a strong antimicrobial agent with high potential in wound treatment

Abstract

Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.

Country
Serbia
Keywords

Wound treatment, Alginates, Cell Survival, Biocompatible Materials, Microbial Sensitivity Tests, Antimicrobial activity, Lignin, Hydrogel, Polyethylene Glycol Dimethacrylate, Cell Line, Anti-Infective Agents, Glucuronic Acid, Humans, Bacterial biofilm, Drug Carriers, Bacteria, Hexuronic Acids, Alginate, Lignin model polymer, Epithelial Cells, Biofilms, Wounds and Injuries

  • BIP!
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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    45
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
  • citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    45
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
45
Top 10%
Average
Average
bronze