Immunogenicity of recombinant polytope constructs containing protective group A streptococcal antigens, J14 and H12

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Apr 2006 Australia English Publisher:Elsevier BVJournal:International Congress Series, volume 1,289, pages 320-323 (issn: 0531-5131,

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Authors: Georgousakis M.M.; Sriprakash K.S.; Good M.F.; Batzloff M.R.;

doi: 10.1016/j.ics.2005.10.034

Immunogenicity of recombinant polytope constructs containing protective group A streptococcal antigens, J14 and H12

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Abstract

A number of polytope recombinant proteins were constructed that contained two group A streptococcal (GAS) protective epitopes, J14 and H12, in various combinations and molar ratios. The ability of each of these polytopes to stimulate an immune response to both of the antigens was tested in a murine model. Antigen-specific serum IgG varied between polytope constructs, indicating that the relative position of J14 and H12 influences the immune response and may need to be considered in multi-epitope vaccine design containing these antigens.

Country

Australia

Related Organizations

University of Queensland
Australia
University of Queensland
Australia
QIMR Berghofer Medical Research Institute
Australia

Keywords

Multivalent, Sfb1, 2700 Medicine, Group A streptococcus, M-protein, Vaccine

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