Structural domains in RNAi
Copyright policy )Structural domains in RNAi
Structural and biochemical studies have begun to elucidate the pathway of RNA silencing that leads to the formation of the RISC complex. The outstanding feature of this pathway is the precise recognition and processing of double‐stranded RNA. We present a review of recent structures that illustrate the molecular mechanisms contributing to these two related functions, highlighting models of Drosha, Dicer, and RISC function.
- Emory University United States
- EMORY UNIVERSITY
Models, Molecular, Ribonuclease III, Pyrococcus, PAZ, Protein Conformation, Ribonuclease H, Crystallography, X-Ray, Catalytic Domain, dsRBD, Animals, Humans, RNA-Induced Silencing Complex, RNaseIII, Gene Silencing, RNA, Double-Stranded, Binding Sites, PIWI, Protein Structure, Tertiary, Argonaute, MicroRNAs, Genetic Techniques, RNA, RNA Interference
Models, Molecular, Ribonuclease III, Pyrococcus, PAZ, Protein Conformation, Ribonuclease H, Crystallography, X-Ray, Catalytic Domain, dsRBD, Animals, Humans, RNA-Induced Silencing Complex, RNaseIII, Gene Silencing, RNA, Double-Stranded, Binding Sites, PIWI, Protein Structure, Tertiary, Argonaute, MicroRNAs, Genetic Techniques, RNA, RNA Interference
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