This article focuses on the medically relevant arachnid species found in North America and selected other arachnids from around the world. While it is largely still true that the geographic location of the envenomation assists in determining the species responsible, the booming trade in arachnids as exotic pets should prompt the clinician to inquire into this possibility. Expert advice should be sought in either case; species identification is critical in determining the need for and proper type of antivenom therapy.