publication . Article . Conference object . 2017

Challenges of dosimetry of ultra-short pulsed very high energy electron beams

A. Subiel; Vadim Moskvin; Gregor H. Welsh; Silvia Cipiccia; D. Reboredo; Colleen DesRosiers; Dino A. Jaroszynski;
Open Access English
  • Published: 30 Oct 2017 Journal: Physica Medica, volume 42, pages 327-331 (issn: 11201797, Copyright policy)
Abstract
Abstract Very high energy electrons (VHEE) in the range from 100 to 250 MeV have the potential of becoming an alternative modality in radiotherapy because of their improved dosimetric properties compared with 6–20 MV photons generated by clinical linear accelerators (LINACs). VHEE beams have characteristics unlike any other beams currently used for radiotherapy: femtosecond to picosecond duration electron bunches, which leads to very high dose per pulse, and energies that exceed that currently used in clinical applications. Dosimetry with conventional online detectors, such as ionization chambers or diodes, is a challenge due to non-negligible ion recombination ...
Persistent Identifiers
Subjects
arXiv: Physics::Medical PhysicsPhysics::Accelerator PhysicsPhysics::Instrumentation and Detectors
free text keywords: QC, Biophysics, General Physics and Astronomy, Radiology Nuclear Medicine and imaging, General Medicine, Electron, Ionization chamber, Femtosecond, Ion, Ionization, Physics, Optics, business.industry, business, Linear particle accelerator, Dosimetry, Atomic physics, Cathode ray
Funded by
EC| EUCARD-2
Project
EUCARD-2
Enhanced European Coordination for Accelerator Research & Development
  • Funder: European Commission (EC)
  • Project Code: 312453
  • Funding stream: FP7 | SP4 | INFRA
,
RCUK| External beam therapy using very high energy electrons generated by laser-plasma wake-field accelerators
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: ST/H003703/1
  • Funding stream: STFC
,
RCUK| Lab in a bubble
Project
  • Funder: Research Council UK (RCUK)
  • Project Code: EP/N028694/1
  • Funding stream: EPSRC
,
EC| EuPRAXIA
Project
EuPRAXIA
Proposal for a Horizon 2020 Design Study on the “European Plasma Research Accelerator with eXcellence In Applications“ (EuPRAXIA)
  • Funder: European Commission (EC)
  • Project Code: 653782
  • Funding stream: H2020 | RIA
,
EC| LASERLAB-EUROPE
Project
LASERLAB-EUROPE
The Integrated Initiative of European Laser Research Infrastructures III
  • Funder: European Commission (EC)
  • Project Code: 284464
  • Funding stream: FP7 | SP4 | INFRA
26 references, page 1 of 2

[1] DesRosiers CM. An evaluation of very high energy electron beams (up to 250 MeV) in radiation therapy. Indiana, USA: Prude University; 2004.

[2] Nakajima K. Laser-driven electron beam and radiation sources for basic medical and industrial sciences. Proceedings of the Japan Academy Series BPhysical and Biological Sciences. 2015;91:223-45.

[3] SCAPA. <http://www.scapa.ac.uk/?page_id=70>; 2016 [accessed 08.12.16].

[4] SPARC. <http://www.lnf.infn.it/acceleratori/sparc/>; 2016 [accessed 28.11.16].

[5] NLCTA. <https://www6.slac.stanford.edu/blog-tags/next-linear-collider-testaccelerator-nlcta>; 2016 [accessed 08.12.16].

[6] DesRosiers C, Moskvin V, Bielajew AF, Papiez L. 150-250 MeV electron beams in radiation therapy. Phys Med Biol. 2000;45:1781-805.

[7] Fuchs T, Szymanowski H, Oelfke U, Glinec Y, Rechatin C, Faure J, et al. Treatment planning for laser-accelerated very-high energy electrons. Phys Med Biol 2009;54:3315-28.

[8] Yeboah C, Sandison GA. Optimized treatment planning for prostate cancer comparing IMPT, VHEET and 15 MV IMXT. Phys Med Biol 2002;47:2247-61.

[9] DesRosiers C, Moskvin V, Cao M, Joshi C, Langer M. Lung tumor treatment with very high energy electron beams of 150-250 Mev as compared to conventional megavoltage photon beams. International Journal of Radiation Oncology Biology Physics 2008;72. S612-S.

[10] DesRosiers C, Moskvin V, Cao M, Joshi CJ, Langer M. Laser-plasma generated very high energy electrons in radiation therapy of the prostate. Proceedings of SPIE; 2008. p. 688109.

[11] Yeboah C, Sandison GA, Moskvin V. Optimization of intensity-modulated very high energy (50-250 MeV) electron therapy. Phys Med Biol 2002;47:1285-301.

[12] Bazalova-Carter M, Qu B, Palma B, Hardemark B, Hynning E, Jensen C, et al. Treatment planning for radiotherapy with very high-energy electron beams and comparison of VHEE and VMAT plans. Med Phys 2015;42:2615-25.

[13] Subiel A, Moskvin V, Welsh GH, Cipiccia S, Reboredo D, Evans P, et al. Dosimetry of very high energy electrons (VHEE) for radiotherapy applications: using radiochromic film measurements and Monte Carlo simulations. Phys Med Biol. 2014;59:5811-29.

[14] IAEA. Absorbed dose determination in external beam radiotherapy. Vienna: IAEA; 2000.

[15] Thwaites DI, DuSautoy AR, Jordan T, McEwen MR, Nisbet A, Nahum AE, et al. The IPEM code of practice for electron dosimetry for radiotherapy beams of initial energy from 4 to 25 MeV based on an absorbed dose to water calibration. Phys Med Biol 2003;48:2929-70. [OpenAIRE]

26 references, page 1 of 2
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