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Publication . Article . Other literature type . 2015

Environmental concentrations of benz[a]anthracene induce developmental defects and DNA damage and impair photomotor response in Japanese medaka larvae

Florane Le Bihanic; Vivien Sommard; de Lansalut Perrine; Anaïk Pichon; Julie Grasset; Saadia Berrada; Hélène Budzinski; +3 Authors
Open Access
English
Published: 01 Mar 2015
Publisher: Academic Press Inc Elsevier Science
Country: France
Abstract

Benz[a]anthracene (BaA) is a ubiquitous polycyclic aromatic hydrocarbon found in numerous aquatic ecosystems. However, ecotoxicological data in aquatic organisms are scarce. To remedy this lack of data, Japanese medaka (Oryzias latipes) embryos were exposed to BaA and toxic effects were investigated at multiple toxicological endpoints. Japanese medaka embryos were incubated onto BaA-spiked artificial sediment for 9 days at low or moderate environmental concentrations ranging from 0.9 to 12µgg(-1) dw. BaA-exposed embryos exhibited significant tachycardia. BaA exposure was also shown to increase CYP1A activity in the hepato-biliary tissue as well as craniofacial deformities and DNA damage in pro-larvae. The photomotor response of BaA-exposed larvae was reduced in comparison to the control group. According to this set of tests, the lowest tested and observed effect concentration (LOEC) for Japanese medaka early life stages was equivalent to 0.92µgg(-1) dw of BaA. This concentration fall into the range of concentrations frequently encountered in sediments of polluted aquatic ecosystems. Taking into consideration these results, BaA represents a threat for fish early life stages in particular those developing onto or into contaminated sediments.

Subjects by Vocabulary

Medical Subject Headings: animal structures

Microsoft Academic Graph classification: Benz(a)anthracene chemistry.chemical_compound chemistry Environmental chemistry Aquatic ecosystem Larva Biology Oryzias biology.organism_classification DNA damage Embryo Polycyclic aromatic hydrocarbon chemistry.chemical_classification Japanese Medaka

Subjects

Benz[a]anthracene, Spiked sediment, Teratogenicity, DNA damage, Swimming behavior, In vivo EROD activity, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Pollution, General Medicine, benz[a]anthracene, spiked sediment, swimming behavior, teratogenicity, dna damage, in vivo erod activity, [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology

Arcaro, K. F., O'Keefe, P. W., Yang, Y., Clayton, W., Gierthy, J. F., 1999. Antiestrogenicity of environmental polycyclic aromatic hydrocarbons in human breast cancer cells. Toxicology. 133, 115-127.

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