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Embryology of the Parathyroid Glands

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2018 English Publisher:Elsevier BVJournal:Endocrinology and Metabolism Clinics of North America, volume 47, pages 733-742 (issn: 0889-8529,

Authors: Nancy R. Manley; Brian G. Condie; Kristen Peissig;

doi: 10.1016/j.ecl.2018.07.002

pmid: 30390809

pmc: PMC6226091

Embryology of the Parathyroid Glands

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Abstract

The parathyroid glands are essential for regulating calcium homeostasis in the body. The genetic programs that control parathyroid fate specification, morphogenesis, differentiation, and survival are only beginning to be delineated, but are all centered around a key transcription factor, GCM2. Mutations in the Gcm2 gene as well as in several other genes involved in parathyroid organogenesis have been found to cause parathyroid disorders in humans. Therefore, understanding the normal development of the parathyroid will provide insight into the origins of parathyroid disorders.

Related Organizations

University of Georgia Press
United States
University of Georgia
Georgia

Keywords

Parathyroid Glands, Gene Expression Regulation, Parathyroid Hormone, Animals, Humans, Nuclear Proteins, Transcription Factors

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