publication . Article . 2016

Oral vaccination of fish: Lessons from humans and veterinary species

Carmen W.E. Embregts; Maria Forlenza;
Open Access English
  • Published: 01 Jan 2016 Journal: Developmental & Comparative Immunology (issn: 0145305X, Copyright policy)
  • Publisher: The Authors. Published by Elsevier Ltd.
  • Country: Netherlands
AbstractThe limited number of oral vaccines currently approved for use in humans and veterinary species clearly illustrates that development of efficacious and safe oral vaccines has been a challenge not only for fish immunologists. The insufficient efficacy of oral vaccines is partly due to antigen breakdown in the harsh gastric environment, but also to the high tolerogenic gut environment and to inadequate vaccine design. In this review we discuss current approaches used to develop oral vaccines for mass vaccination of farmed fish species. Furthermore, using various examples from the human and veterinary vaccine development, we propose additional approaches to...
Persistent Identifiers
free text keywords: Live vaccines, Adenoviruses, Encapsulation, M-like cells, Adjuvants, Zebrafish, Immunology, Developmental Biology, Mucosal immunology, Mass vaccination, Animal model, Aquaculture, business.industry, business, Immunology, Fish species, Medicine, Fish farming, Veterinary medicine, Encapsulation (computer programming), Vaccination
Related Organizations
Funded by
NWO| Improving vaccination of carp against spring viraemia of carp virus (SVCV) and Koi Herpes Virus (KHV)
  • Funder: Netherlands Organisation for Scientific Research (NWO) (NWO)
  • Project Code: 2300161405
Targeted disease prophylaxis in European fish farming
  • Funder: European Commission (EC)
  • Project Code: 311993
  • Funding stream: FP7 | SP1 | KBBE
Fisheries and Aquaculture ManagementFAM Projects: Targeted disease prophylaxis in European fish farming
European Marine ScienceMarine Environmental Science: Targeted disease prophylaxis in European fish farming
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