Chromosome Segregation: Reconstituting the Kinetochore

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2016 English Publisher:Elsevier BVJournal:Current Biology, volume 26, pages R1242-R1245 (issn: 0960-9822,

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Authors: Frederick G, Westhorpe; Aaron F, Straight;

doi: 10.1016/j.cub.2016.09.051

pmid: 27923136

Chromosome Segregation: Reconstituting the Kinetochore

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Abstract

Faithful chromosome segregation is accomplished by attachment of chromosomes to spindle microtubules using the kinetochore. In a major step forward in understanding the functional and structural complexity of kinetochores, a 21-subunit human centromere - kinetochore complex has been reconstituted entirely from purified components, recreating the connection between DNA and microtubule.

Related Organizations

Stanford University
United States

Keywords

Chromosome Segregation, Eukaryota, Mitosis, Kinetochores, Microtubules

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Insights from biochemical reconstitution into the architecture of human kinetochores
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