publication . Other literature type . Preprint . Article . 2020

Self-adaptive Biosystems Through Tunable Genetic Parts and Circuits

Vittorio Bartoli; Mario di Bernardo; Thomas E. Gorochowski;
Open Access
  • Published: 06 Oct 2020
  • Publisher: MDPI AG
Abstract
Biological systems often need to operate in complex environments where conditions can rapidly change. This is possible due to their inherent ability to sense changes and adapt by adjusting their behavior in response. Here, we detail recent advances in the creation of synthetic genetic parts and circuits whose behaviors can be dynamically tuned through a variety of intra- and extra-cellular signals. We show how this capability lays the foundation for implementing control engineering schemes in living cells and allows for the creation of biological systems that are able to self-adapt, ensuring their functionality is maintained in the face of varying environmental ...
Subjects
free text keywords: biotechnology, biochemistry, Synthetic biology, Systems biology, Electronic circuit, Computer science, Self adaptive, Electronic engineering, Distributed computing, Software deployment
Funded by
UKRI| BrisSynBio: Bristol Centre for Synthetic Biology
Project
  • Funder: UK Research and Innovation (UKRI)
  • Project Code: BB/L01386X/1
  • Funding stream: BBSRC
,
EC| COSY-BIO
Project
COSY-BIO
Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
  • Funder: European Commission (EC)
  • Project Code: 766840
  • Funding stream: H2020 | RIA
Validated by funder
,
UKRI| EPSRC and BBSRC Centre for Doctoral Training in Synthetic Biology
Project
  • Funder: UK Research and Innovation (UKRI)
  • Project Code: EP/L016494/1
  • Funding stream: EPSRC
Communities
FET H2020FET OPEN: FET-Open research and innovation actions
FET H2020FET OPEN: Control Engineering of Biological Systems for Reliable Synthetic Biology Applications
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