Lung cancer is a worldwide high-risk disease, and lung nodules are the main manifestation of early lung cancer. Automatic detection of lung nodules reduces the workload of radiologists, the rate of misdiagnosis and missed diagnosis. For this purpose, we propose a Faster R-CNN algorithm for the detection of these lung nodules.Faster R-CNN algorithm can detect lung nodules, and the training set is used to prove the feasibility of this technique. In theory, parameter optimization can improve network structure, as well as detection accuracy.Through experiments, the best parameters are that the basic learning rate is 0.001, step size is 70,000, attenuation coefficient is 0.1, the value of Dropout is 0.5, and the value of Batch Size is 64. Compared with other networks for detecting lung nodules, the optimized and improved algorithm proposed in this paper generally improves detection accuracy by more than 20% when compared with the other traditional algorithms.Our experimental results have proved that the method of detecting lung nodules based on Faster R-CNN algorithm has good accuracy and therefore, presents potential clinical value in lung disease diagnosis. This method can further assist radiologists, and also for researchers in the design and development of the detection system for lung nodules.