TXNIP Switches Tracks toward a Terminal UPR

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2012 English Publisher:Elsevier BVJournal:Cell Metabolism, volume 16, pages 135-137 (issn: 1550-4131,

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Authors: Anthony, Tracy G.; Wek, Ronald C.;

doi: 10.1016/j.cmet.2012.07.012

pmid: 22883225

TXNIP Switches Tracks toward a Terminal UPR

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Abstract

During the progression of diabetes, crosstalk between ER stress and inflammation controls islet cell fate. In this issue, Lerner et al. (2012) and Oslowski et al. (2012) discover that thioredoxin-interacting protein (TXNIP) is a regulatory switch connecting the terminal unfolded protein response (UPR) and NLRP3 inflammasome to mediate β cell death.

Related Organizations

Indiana University
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Rutgers, The State University of New Jersey
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Indiana University School of Medicine
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Keywords

Physiology, Cell Biology, Molecular Biology

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