Osteoclasts Pump Iron
Copyright policy )Osteoclasts Pump Iron
Osteoclasts are the primary cells that resorb bone; they require high energy levels to degrade bone matrix, releasing minerals to maintain calcium homeostasis. Recent work on osteoclast differentiation and activity highlights an important role for mitochondrial biogenesis and explores the role of iron transferrin in generating a positive osteoclastogenic feedback loop.
- University of Pittsburgh United States
- Veterans Health Administration United States
Organelle Biogenesis, Physiology, Iron, Transferrin, Osteoclasts, Cell Differentiation, Cell Biology, CREB-Binding Protein, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Mitochondria, Mice, Gene Knockdown Techniques, Receptors, Transferrin, Trans-Activators, Animals, Bone Resorption, Reactive Oxygen Species, Molecular Biology, Transcription Factors
Organelle Biogenesis, Physiology, Iron, Transferrin, Osteoclasts, Cell Differentiation, Cell Biology, CREB-Binding Protein, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Mitochondria, Mice, Gene Knockdown Techniques, Receptors, Transferrin, Trans-Activators, Animals, Bone Resorption, Reactive Oxygen Species, Molecular Biology, Transcription Factors
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