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Rotavirus

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2015 English Publisher:Elsevier BVJournal:Clinics in Laboratory Medicine, volume 35, pages 363-391 (issn: 0272-2712,

Authors: Mathew D, Esona; Rashi, Gautam;

doi: 10.1016/j.cll.2015.02.012

pmid: 26004648

Rotavirus

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Abstract

Group A rotavirus (RVA) is the major cause of acute gastroenteritis (AGE) in young children worldwide. Introduction of two live, attenuated rotavirus vaccines, Rotarix® and RotaTeq®, has dramatically reduced RVA-associated AGE and mortality. High-throughput, sensitive and specific techniques are required to rapidly diagnose and characterize rotavirus strains in stool samples for proper patient treatment and to monitor circulating vaccine and wild-type rotavirus strains. New molecular assays are rapidly developed that are more sensitive and specific than the conventional assays for detection, genotyping and full genome characterization of circulating rotavirus wild-type and vaccine (Rotarix® and RotaTeq®) strains causing AGE.

Related Organizations

Centers for Disease Control and Prevention
United States

Keywords

Rotavirus, Virus Cultivation, Genotyping Techniques, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, RNA, High-Throughput Nucleotide Sequencing, Real-Time Polymerase Chain Reaction, Rotavirus Infections, Gastroenteritis, Immunoenzyme Techniques, Agglutination Tests, Humans

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	83
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%