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HBV/HCV Coinfection in the Era of HCV-DAAs

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2019 English Publisher:Elsevier BVJournal:Clinics in Liver Disease, volume 23, pages 463-472 (issn: 1089-3261,

Authors: Mohamed El Kabany; Beshoy Yanny; Rashed Abdelaal;

doi: 10.1016/j.cld.2019.04.003

pmid: 31266620

HBV/HCV Coinfection in the Era of HCV-DAAs

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Abstract

Epidemiologic studies suggest that 10% to 15% of patients infected with hepatitis C virus (HCV) are coinfected with hepatitis B virus (HBV) in the United States as a result of the shared modality of transmission, but the true prevalence is not known. The progression of liver disease to cirrhosis and hepatocellular carcinoma is generally faster in patients who are coinfected, and HCV is usually more predominant. Immunosuppression of the host or eradication of hepatitis C can change this paradigm, causing hepatitis B reactivation. This review describes HCV-HBV viral interactions, risks for reactivation, screening, and society guidelines for surveillance and treatment.

Related Organizations

University of Chicago
United States
University of California, Los Angeles
United States

Keywords

Liver Cirrhosis, Male, Hepatitis B virus, Carcinoma, Hepatocellular, Coinfection, Liver Neoplasms, Comorbidity, Hepacivirus, Hepatitis B, Hepatitis C, Risk Assessment, Survival Analysis, United States, Disease Progression, Prevalence, Humans, Female

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	19
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%