descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2018 English Publisher:Elsevier BVJournal:Cell Host & Microbe, volume 24, pages 181-183 (issn: 1931-3128,

Authors: Julian A. Hiscox; Julian A. Hiscox; Lisa F. P. Ng; Lisa F. P. Ng;

doi: 10.1016/j.chom.2018.07.014

pmid: 30092190

Viperin Poisons Viral Replication

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Abstract

Control of virus infection relies on the stimulation of interferon-stimulated genes (ISGs) that inhibit viral replication. In a recent Nature paper, Gizzi et al. (2018) discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering insights into drug design.

Related Organizations

University of Liverpool
United Kingdom
Agency for Science, Technology and Research
Singapore
National Institute for Health Research
United Kingdom

Keywords

Genome, Human, Humans, Proteins, Ribonucleotides, Virus Replication, Antiviral Agents, Poisons

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