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Publication . Article . 2020

Pulmonary Functional MRI and CT in a Survivor of Bronchiolitis and Respiratory Failure Caused by e-Cigarette Use

Rachel L. Eddy; Hana Serajeddini; Danielle Knipping; Simon T. Landman; Karen J. Bosma; Constance A. Mackenzie; Inderdeep Dhaliwal; +1 Authors
Closed Access
Published: 01 Oct 2020 Journal: Chest, volume 158, pages e147-e151 (issn: 0012-3692, Copyright policy )
Publisher: Elsevier BV
Abstract

Although nearly 3,000 e-cigarette-related hospitalizations have been reported in North America, the long-term outcomes in these patients have not been described. We followed an 18-year-old boy who survived acute critical illness and respiratory failure related to 5 months of e-cigarette use. Chronic irreversible airflow obstruction and markedly abnormal 129Xe MRI ventilation heterogeneity was observed and persisted 8 months after hospital discharge, despite improvement in quality-of-life and chest CT findings. Lung clearance index and oscillometry measures were also highly abnormal at 8 months postdischarge. Although 129Xe MRI ventilation abnormalities were dominant in the lung apices and central lung regions, the pattern of ventilation defects was dissimilar to ventilation heterogeneity observed in patients with obstructive lung disease, such as asthma and COPD. Our findings underscore the long-term functional impacts of e-cigarette-related lung injury in survivors of critical illness; longitudinal evaluations may shed light on the pathophysiologic mechanisms that drive e-cigarette-related lung disease.

Subjects by Vocabulary

Microsoft Academic Graph classification: Cardiology medicine.medical_specialty medicine Asthma medicine.disease business.industry business COPD Lung injury Internal medicine Bronchiolitis Lung medicine.anatomical_structure Respiratory failure Breathing Obstructive lung disease

Medical Subject Headings: respiratory tract diseases

Subjects

Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, Pulmonary and Respiratory Medicine

Related Organizations
Funded by
NSERC
Project
  • Funder: Natural Sciences and Engineering Research Council of Canada (NSERC)
,
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
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