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Designing Chimeric LOV Photoswitches

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2012 English Publisher:Elsevier BVJournal:Chemistry & Biology, volume 19, pages 441-442 (issn: 1074-5521, Copyright policy )
Authors: Woolley, G. Andrew;

doi: 10.1016/j.chembiol.2012.04.003

pmid: 22520749

Designing Chimeric LOV Photoswitches

Abstract

The LOV domain from Avena sativa has a C-terminal (Jα) helix that dissociates and unfolds when the protein is exposed to blue light. Using computational protein design methods, Lungu et al., in this issue of Chemistry & Biology, created chimeric Jα sequences that show photo-controlled interactions with chosen targets.

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Keywords

Pharmacology, Clinical Biochemistry, Drug Discovery, Molecular Medicine, Biochemistry, Molecular Biology

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    popularity
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    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
105
Top 10%
Top 10%
Top 10%
hybrid
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