publication . Article . 2019

CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions

Johannes Jung; Sonja Buisman; Ellen Weersing; Albertina Dethmers-Ausema; Erik Zwart; Hein Schepers; Mike R. Dekker; Seka Lazare; Franziska Hammerl; Yulia Skokova; ...
Open Access English
  • Published: 12 Feb 2019
  • Country: Netherlands
Abstract
Summary: In this study, we demonstrate that, among all five CBX Polycomb proteins, only CBX7 possesses the ability to control self-renewal of human hematopoietic stem and progenitor cells (HSPCs). Xenotransplantation of CBX7-overexpressing HSPCs resulted in increased multi-lineage long-term engraftment and myelopoiesis. Gene expression and chromatin analyses revealed perturbations in genes involved in differentiation, DNA and chromatin maintenance, and cell cycle control. CBX7 is upregulated in acute myeloid leukemia (AML), and its genetic or pharmacological repression in AML cells inhibited proliferation and induced differentiation. Mass spectrometry analysis r...
Subjects
free text keywords: General Biochemistry, Genetics and Molecular Biology, lcsh:Biology (General), lcsh:QH301-705.5, Haematopoiesis, Chromatin, Methyltransferase, Chromatin maintenance, Myeloid leukemia, Progenitor cell, Biology, Myelopoiesis, Leukemia, medicine.disease, medicine, Cell biology
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