SnapShot: CGAS-STING Signaling

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2018 English Publisher:Elsevier BVJournal:Cell, volume 173, pages 276-2,760 (issn: 0092-8674,

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Authors: Lorenzo, Galluzzi; Claire, Vanpouille-Box; Samuel F, Bakhoum; Sandra, Demaria;

doi: 10.1016/j.cell.2018.03.015

pmid: 29570996

SnapShot: CGAS-STING Signaling

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Abstract

CGAS responds to cytosolic DNA by initiating a STING-dependent response that ultimately engages innate immune effectors to ensure the preservation of organismal homeostasis.

Related Organizations

University of Paris
France
Memorial Sloan Kettering Cancer Center
United States
Cornell University
United States

Keywords

NF-kappa B, Membrane Proteins, Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase, Protein Serine-Threonine Kinases, Nucleotidyltransferases, Immunity, Innate, STING Protein, Cellular Microenvironment, NF-kappaB-Inducing Kinase, Humans, Signal Transduction

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