A Bcl-xL Timer Sets Platelet Life Span

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2007 English Publisher:Elsevier BVJournal:Cell, volume 128, pages 1,035-1,036 (issn: 0092-8674,

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Authors: Qi, Bing; Hardwick, J. Marie;

doi: 10.1016/j.cell.2007.03.002

pmid: 17382877

A Bcl-xL Timer Sets Platelet Life Span

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Abstract

Platelets are cell fragments lacking nuclei that play a key role in blood clotting. Using an impressive genetic screen involving ENU-mutagenesis of whole mice, Mason et al. (2007) report in this issue their identification of mutations in the antiapoptotic protein Bcl-x(L) that cause accelerated death of platelets leading to platelet deficiency.

Related Organizations

Johns Hopkins University
United States

Keywords

Blood Platelets, Mice, Cell Death, Biochemistry, Genetics and Molecular Biology(all), Cell Survival, Mutagenesis, bcl-X Protein, Animals

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