TOPping up ATR Activity
Copyright policy )TOPping up ATR Activity
The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.
DNA Repair, Models, Genetic, Biochemistry, Genetics and Molecular Biology(all), Nuclear Proteins, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Protein Serine-Threonine Kinases, Xenopus Proteins, DNA-Binding Proteins, Enzyme Activation, Gene Expression Regulation, Animals, Humans, Carrier Proteins
DNA Repair, Models, Genetic, Biochemistry, Genetics and Molecular Biology(all), Nuclear Proteins, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Protein Serine-Threonine Kinases, Xenopus Proteins, DNA-Binding Proteins, Enzyme Activation, Gene Expression Regulation, Animals, Humans, Carrier Proteins
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