
The spindle assembly checkpoint (SAC) is a feedback control system that monitors the state of kinetochore/microtubule attachment during mitosis and halts cell cycle progression until all chromosomes are properly aligned at the metaphase plate. The state of chromosome-microtubule attachment is implicated as a crucial factor in the checkpoint response. On the contrary, lack of tension in the centromere-kinetochore region of sister chromatids has been shown to regulate a pathway of correction of undesired chromosome-microtubule connections, while the presence of tension is believed to promote the stabilization of attachments. We discuss how tension-sensitive phenomena, such as attachment correction and stabilization, relate to the SAC and we speculate on the existence of a single pathway linking error correction and SAC activation.
Mitosis, Cell Cycle Proteins, Spindle Apparatus, Chromatids, Protein Serine-Threonine Kinases, Microtubules, Models, Biological, Aurora Kinases, Chromosome Segregation, Animals, Humans, Kinetochores, Biologie
Mitosis, Cell Cycle Proteins, Spindle Apparatus, Chromatids, Protein Serine-Threonine Kinases, Microtubules, Models, Biological, Aurora Kinases, Chromosome Segregation, Animals, Humans, Kinetochores, Biologie
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