mTORC1 gRABs the Golgi

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2014 English Publisher:Elsevier BVJournal:Cancer Cell, volume 26, pages 601-603 (issn: 1535-6108,

Copyright policy )Funded by:NIH | Mechanistic Target of Rap...

Authors: Sanchez-Gurmaches, Joan; Guertin, David A.;

doi: 10.1016/j.ccell.2014.10.011

pmid: 25517745

mTORC1 gRABs the Golgi

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Abstract

A lysosome-based mechanism of amino acid sensing by mTORC1 regulated by Rag GTPases has emerged. In this issue of Cancer Cell, Thomas and colleagues propose a Golgi-based and Rag-independent mechanism mediated by the Rab1A GTPase. Furthermore, Rab1A overexpression in colorectal cancers correlates with mTORC1 activity and sensitivity to mTOR inhibitors.

Related Organizations

University of Massachusetts Medical School
United States

Keywords

rab1 GTP-Binding Proteins, Cancer Research, Oncology, Animals, Humans, Female, Cell Biology, Colorectal Neoplasms

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