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Carbohydrate Research
Article . 2004 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
Carbohydrate Research
Article . 2004
Data sources: Europe PubMed Central
Carbohydrate Research
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The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2004 English Publisher:Elsevier BVJournal:Carbohydrate Research, volume 339, pages 699-703 (issn: 0008-6215, Copyright policy )
Authors: Carl S. Rye; Stephen G. Withers;

doi: 10.1016/j.carres.2003.12.011

pmid: 15013408

The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases

Abstract

A thio-linked disaccharide based on the structure of the glycosaminoglycan chondroitin was synthesized as a potential inhibitor of chondroitin AC lyase from Flavobacterium heparinum for structural analysis of the active site. Instead it was found to be a slow substrate, thereby demonstrating that lyases, in contrast to glycosidases, can cleave thioglycoside links between sugars.

Related Organizations
Keywords

Kinetics, Carbohydrate Sequence, Molecular Structure, Sulfhydryl Compounds, Disaccharides, Chondroitin, Flavobacterium, Polysaccharide-Lyases

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    		 49
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
49
Top 10%
Top 10%
Top 10%
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