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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Cancer Lettersarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Cancer Letters
Article . 2005 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
Cancer Letters
Article . 2005
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/j.c...
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Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2005 English Publisher:Elsevier BVJournal:Cancer Letters, volume 222, pages 119-124 (issn: 0304-3835, Copyright policy )
Authors: Jean L, Lord; Ann, de Peyster; P J E, Quintana; Robert P, Metzger;

doi: 10.1016/j.canlet.2004.09.009

pmid: 15837549

Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells

Abstract

Human mammary carcinoma MCF-7 cell line responsiveness to the pteridines xanthopterin and isoxanthopterin was studied using the MTS assay for measurement of cell viability. The pteridines were tested at concentrations ranging from 7.8 to 500 microM singly and in 11 isoxanthopterin:xanthopterin ratios. IC50s of xanthopterin and isoxanthopterin were 109+/-13 microM (mean+/-SEM of y estimate) and 103+/-9 microM, respectively. The IC50 values for pteridine mixtures were similar although 3:1 and 4:1 isoxanthopterin:xanthopterin ratios seemed slightly more cytotoxic than other mixtures. However, ANOVA revealed no statistical differences in the cytotoxicity of mixtures.

Related Organizations
Keywords

Drug Combinations, Inhibitory Concentration 50, Cell Survival, Cell Line, Tumor, Humans, Antineoplastic Agents, Breast Neoplasms, Drug Synergism, Xanthopterin

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Average
Average
Average
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