Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
Copyright policy ) Betty, Lam; Zhiyuan, Zhang; Jeffery A, Stafford; Robert J, Skene; Lihong, Shi; Stephen L, Gwaltney;
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and selective DPP-4 inhibitors.
- Takeda (Japan) Japan
Enzyme Activation, Models, Molecular, Dipeptidyl-Peptidase IV Inhibitors, Inhibitory Concentration 50, Dose-Response Relationship, Drug, Catalytic Domain, Drug Design, Humans, Pyrimidinones, Crystallography, X-Ray
Enzyme Activation, Models, Molecular, Dipeptidyl-Peptidase IV Inhibitors, Inhibitory Concentration 50, Dose-Response Relationship, Drug, Catalytic Domain, Drug Design, Humans, Pyrimidinones, Crystallography, X-Ray
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 23
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