Benzyl prolinate derivatives as novel selective KCC2 blockers
Copyright policy ) Cécile, Pégurier; Nathalie, Bosman; Philippe, Collart; Marie-Laure, Delporte; Karine, Leclercq; Sébastien, Lengelé; Ananda Kumar, Kanduluru; +6 Authors
Cécile, Pégurier; Nathalie, Bosman; Philippe, Collart; Marie-Laure, Delporte; Karine, Leclercq; Sébastien, Lengelé; Ananda Kumar, Kanduluru; Stéphane, Meunier; Nathalie, Pacico; Lakshmana Rao, Vadali; Alain, Wagner; Christian, Wolff; Laurent, Provins;
Benzyl prolinate derivatives as novel selective KCC2 blockers
The discovery and optimization of a novel class of selective submicromolar KCC2 blockers is described. Details of synthesis and SAR are given together with ADME properties of selected compounds. A methylsulfone residue on the R(1) phenyl group improved the overall general profile of these prolinate derivatives.
- UCB Pharma (Belgium) Belgium
- University of Strasbourg France
Structure-Activity Relationship, Proline, Symporters, K Cl- Cotransporters, Animals, Stereoisomerism, Rats
Structure-Activity Relationship, Proline, Symporters, K Cl- Cotransporters, Animals, Stereoisomerism, Rats
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 11
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