Synthesis and antiproliferative activity of retroetoposide

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2003 English Publisher:Elsevier BVJournal:Bioorganic & Medicinal Chemistry Letters, volume 13, pages 4,107-4,109 (issn: 0960-894X,

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Authors: Philippe, Meresse; Prokopios, Magiatis; Emmanuel, Bertounesque; Claude, Monneret;

doi: 10.1016/j.bmcl.2003.08.044

pmid: 14592517

Synthesis and antiproliferative activity of retroetoposide

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Abstract

Retro-4'-demethyl-4-epipodophyllotoxin 6 was synthesized in eight steps and 10% overall yield from 4'-demethyl-4-epipodophyllotoxin 12. Subsequent coupling of 22 with 1-O-trimethylsilyl-4,6-O-ethylidene-beta-D-glucoside 26 afforded retroetoposide 5 which is 10-fold less cytotoxic than etoposide against L1210 cell line.

Related Organizations

Institute Curie
France
Biomolécules : Conception, Isolement, Synthèse
France

Keywords

Structure-Activity Relationship, Molecular Structure, Molecular Conformation, Antineoplastic Agents, Alkylating, Cell Division, Etoposide

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